The Labour politicians have asked that administrators be stopped from selling players and the club’s 12-point penalty be frozen until an inquiry is complete.
Wigan will fulfil Saturday’s game at Brentford despite players going unpaid.
“We have heard today that staff at the club are about to be made redundant and that players are being offered for sale,” their joint-letter to English Football League chairman Rick Parry says.
“This raises serious concerns about the administration process and fears that the club is being broken up.
“There are also serious questions to be asked about the EFL’s processes, with the club’s new owner being approved just a matter of days before it was plunged into administration.
“This shocking turn of events has left the public of Wigan bewildered and their fate of their football club hanging in the balance.”